| 摘要 |
<p>The present invention relates to construct and methods which allow the expression of immunoglobulins or functional fragments thereof which have been altered so that they are humanised. The expression of the immunoglobulins or fragments thereof takes place in avian cells, and the constructs used have been altered such that the expression levels in avian cells are higher than what would have been expected by simply using a humanised construct. The alterations are based on changing codons so that each amino acid of the codon that is used is the one which is most often found in avians.</p> |
