发明名称 |
USE OF AN URUSHIOL COMPOUND IN PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR INHIBITING SMAD3 PHOSPHORYLATION |
摘要 |
The invention relates to a use of an urushiol compound (code named GQ-5) in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation. We verify that GQ-5 inhibited the interaction of Smad3 with TGF-β type I receptor (TβRI), inhibited subsequent phosphorylation of Smad3, reduced nuclear translocation of Smads complex, and suppressed the transcription of major fibrotic genes such as α-smooth muscle actin (α-SMA), collagen I and fibronectin. Therefore, GQ-5 could be a potent and selective inhibitor of TGF-β1-induced Smad3 phosphorylation, and be used to prepare pharmaceutical compositions for inhibiting Smad3 phosphorylation. |
申请公布号 |
US2015175511(A1) |
申请公布日期 |
2015.06.25 |
申请号 |
US201414531309 |
申请日期 |
2014.11.03 |
申请人 |
Southern Hospital, Southern Medical University ;Kunming Institute of Botany, Chinese Academy of Sciences |
发明人 |
HOU Fan Fan;CHENG Yongxian;NIE Jing;AI Jun;HE Jiangbo |
分类号 |
C07C39/19 |
主分类号 |
C07C39/19 |
代理机构 |
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代理人 |
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主权项 |
1. A use of an urushiol compound in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation. |
地址 |
Guangzhou CN |