发明名称 Peptide Derivatives as Antibiotics
摘要 The present invention relates to antibiotic compounds, methods for producing said compounds, pharmaceutical compositions comprising said compounds, and methods of treatment comprising administering said compounds and/or compositions comprising said compounds.
申请公布号 US2015175659(A1) 申请公布日期 2015.06.25
申请号 US201214342446 申请日期 2012.09.28
申请人 INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE ;NOSOPHARM 发明人 Gualtieri Maxime;Villain-Guillot Philippe;Givaudan Alain;Pages Sylvie
分类号 C07K7/06;A61K45/06;C12P21/02;A61K38/08 主分类号 C07K7/06
代理机构 代理人
主权项 1. A compound of formula (I): Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-NH—(CH2)n—R  (I) wherein Xaa1, Xaa2, Xaa3, Xaa5, Xaa7, Xaa8 and Xaa10 are independently selected from the group consisting of lysine, 3-hydroxylysine, 4-hydroxylysine, 5-hydroxylysine, 3,4-dihydroxylysine, 3,5-dihydroxylysine, 4,5-dihydroxylysine, ornithine, 3-hydroxyornithine, 4-hydroxyornithine, 3,4-dihydroxyornithine, 2,4-diaminobutanoic acid, 3-hydroxy-2,4-diaminobutanoic acid, arginine, histidine, serine, and threonine; Xaa4 is glycine, 3-aminopropanoic acid, or 4-aminobutanoic acid; Xaa6 is proline, 3-hydroxyproline, 4-hydroxyproline, aziridine-2-carboxylic acid, azetidine-2-carboxylic acid, pipecolic acid, 4-oxaproline, 3-thiaproline, 4-thiaproline, 3,4-dehydroproline, 4-aminoproline, 4-fluoroproline, α-methylproline, or α-allylproline; Xaa9 is arginine, 2,3-dehydroarginine, citrulline, 2,3-dehydrocitrulline, canavanine, or 2,3-dehydrocanavanine; n is 2, 3, 4, 5, 6, 7, 8, 9, or 10; and R is —OH, —NH2, or —COOH.
地址 Paris FR