发明名称 |
COMPOSITIONS AND METHODS RELATED TO RECOMBINANT ANTIBODIES TO HISTONE POSTTRANSLATIONAL MODIFICATIONS |
摘要 |
Embodiments concern compositions and methods involving recombinant antibodies to histone post-translational modifications. The invention provides compositions and methods for histone methyltransferase assays. In certain embodiments, the compositions and methods involve a recombinant antibody that binds histone H3 fragment harboring biomarkers such as H3K9me3 mark, H3K4me3 mark, H3K36me3 mark, H3K27me3, H3K9me3 and H3S10phos or a recombinant antibody that binds histone H4 fragment harboring H4K20me3 mark. |
申请公布号 |
WO2014210545(A3) |
申请公布日期 |
2015.06.25 |
申请号 |
WO2014US44716 |
申请日期 |
2014.06.27 |
申请人 |
THE UNIVERSITY OF CHICAGO |
发明人 |
HATTORI, TAKAMITSU;KOIDE, SHOHEI;TAFT, JOSEPH;KOIDE, AKIKO |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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