发明名称 |
Synthetic Polypeptide Libraries And Methods For Generating Naturally Diversified Polypeptide Variants |
摘要 |
<p>The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.</p> |
申请公布号 |
AU2010249470(B2) |
申请公布日期 |
2015.06.25 |
申请号 |
AU20100249470 |
申请日期 |
2010.05.20 |
申请人 |
NOVIMMUNE S.A. |
发明人 |
FISCHER, NICOLAS;KOSCO-VILBOIS, MARIE;RAVN, ULLA;GUENEAU, FRANCK;VENET-BONNOT, SOPHIE |
分类号 |
C12N15/10 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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