发明名称 |
Stem cell-derived retinal pigment epithelial cells |
摘要 |
The present invention relates to a method for promoting directed differentiation of human pluripotent stem cells into retinal pigment epithelium (RPE) fate, the method comprising: a. culturing human pluripotent stem cells in a culture system comprising a basic medium supplemented with nicotinamide (NA) to generate differentiating cells; and b. culturing said differentiating cells in a culture system comprising a basic medium supplemented with one or more members of transforming growth factor ² (TGF ²) superfamily, whereby said human pluripotent stem cells are induced to differentiate into RPE fate. |
申请公布号 |
EP2886646(A1) |
申请公布日期 |
2015.06.24 |
申请号 |
EP20140193621 |
申请日期 |
2008.04.27 |
申请人 |
HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED |
发明人 |
IDELSON, MASHA;ALPER-PINUS, RUSLANA;OBOLENSKY, ALEX;BANIN, EYAL;REUBINOFF, BENJAMIN EITHAN;HEMO, YITZCHAK |
分类号 |
C12N5/079;A61K35/44;A61K35/48;C12N5/071;C12N5/074 |
主分类号 |
C12N5/079 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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