Compositions and methods for targeted thermomodulation

摘要

Provided are nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans.

主权项

1. A topical cosmetic composition comprising:
a cosmetically acceptable carrier; wherein the cosmetically acceptable carrier is configured for topical administration; and a plurality of plasmonic nanoplates with a concentration of 1011 to 1023 particles per ml of composition, wherein the plasmonic nanoplates comprise at least one conductive metal selected from the group consisting of silver, gold, nickel, copper, titanium, silicon, galadium, palladium, platinum, and chromium, wherein the plasmonic nanoplates have a size in a range of 10 nm to 300 nm, wherein the plasmonic nanoplates comprise a coating that coats the conductive metal, wherein the coating comprises silica or polyethylene glycol (PEG), wherein said coating is configured for distributing the plasmonic nanoplates to a target tissue region and for facilitating removal of the plasmonic nanoplates from a skin surface, wherein the plasmonic nanoplates have a peak absorption wavelength of between 750 nm and 1200 nm, wherein the plasmonic nanoplates, upon irradiation with an infrared light source in a range of 750 nm to 1200 nm, induce thermal damage in the target tissue region with which the composition is topically contacted.