Prodefensin-A6 assay method for the in vitro diagnosis of colorectal cancer

摘要

The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Prodefensin-A6 tumour marker in a biological sample taken from a patient suspected of having colorectal cancer, it being possible for said method to be used both in early diagnosis, screening, therapeutic follow-up and prognosis, and in relapse diagnosis in relation to colorectal cancer.

主权项

1. An in vitro method for diagnosing colorectal cancer using a biological sample obtained from a patient suspected of having colorectal cancer, comprising:
assaying for the level of the Prodefensin-A6 protein present in the biological sample using at least one antibody or antibody fraction specific for the Prodefensin-A6 protein; and determining whether the level of the Prodefensin-A6 protein is indicative of the patient having colorectal cancer, wherein the level of the Prodefensin-A6 protein is assayed by detecting any of the signal peptide or the propeptide of the Prodefensin-A6 protein, whether as part of the intact Prodefensin-A6 protein or a fragment thereof, to the exclusion of the mature Defensin-A6 protein or fragments of the mature Defensin-A6 protein.