| 主权项 |
1. A compound of formula IB: wherein: R1 is CY, —C(O)N(R3)2, —C(O)OR3, —C(O)(NH)OH, —C(═NH)NHOH, —C(O)NR3N(R3)2, —C(═N—NH2)NH2, —C(═N)N(R3)2, wherein:
CY is wherein:G2 is —N═, ═N—, or —N(R3′), wherein:each occurrence of R3 and R3′ is independently hydrogen or an optionally substituted C1-6 aliphatic, wherein:X1, X2, and X3, are each independently N, NR3′, O, S, or CR4, provided that only one of X1, X2, or X3 may be O, S, or NR3′;
each occurrence of R4 is independently hydrogen, —CN, halogen, —Z3—R6, or an optionally substituted group selected from C1-6 aliphatic, or 3-10-membered cycloaliphatic, wherein:Z3 is selected from an optionally substituted C1-3 alkylene chain, —O—, —N(R4a)—, —S—, —S(O)—, —S(O)2—, —C(O)—, —CO2—, —C(O)NR4a—, —N(R4a)C(O)—, —N(R4a)CO2—, —S(O)2NR4a—, —N(R4a)S(O)2—, —OC(O)N(R4a)—, —N(R4a)C(O)NR4a—, —N(R4a)S(O)2N(R4a)—, or —OC(O)—;R4a is hydrogen or an optionally substituted C1-4 aliphatic, andR6 is hydrogen or an optionally substituted group selected from C1-6 aliphatic,3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
or wherein two adjacent occurrences of R3′ or R4, taken together with the atom to which they are bound, form an optionally substituted fused group selected from 5-6-membered aryl, or 5-6-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;Ring A is a group selected from 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;each occurrence of R2 is independently —R12a, -T2-R12d, or —V2-T2-R12d, and:each occurrence of R12a is independently halogen, —CN, —NO2, —R12c, —N(R12b)2, —OR12b, —SR12c, —S(O)2R12c, —C(O)R12b, —C(O)OR12b, —C(O)N(R12b)2, —S(O)2N(R12b)2, —OC(O)N(R12b)2, —N(R12e)C(O)R12b, —N(R12e)SO2R12c, —N(R12e)C(O)OR12b, —N(R12e)C(O)N(R12b)2, or —N(R12e)SO2N(R12b)2, or two occurrences of R12b, taken together with a nitrogen atom to which they are bound, form an optionally substituted 4-7-membered heterocyclyl ring having 0-1 additional heteroatoms selected from nitrogen, oxygen, or sulfur;
each occurrence of R12b is independently hydrogen or an optionally substituted group selected from C1-C6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;each occurrence of R12c is independently an optionally substituted group selected from C1-C6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;each occurrence of R12d is independently hydrogen or an optionally substituted from 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;each occurrence of R12e is independently hydrogen or an optionally substituted C1-6 aliphatic group;each occurrence of V2 is independently —N(R12e)—, —O—, —S—, —S(O)—, —S(O)2—, —C(O)—, —C(O)O—, —C(O)N(R12e)—, —S(O)2N(R12e)—, —OC(O)N(R12e)—, —N(R12e)C(O)—, —N(R12e)SO2—, —N(R12e)C(O)O—, —N(R12e)C(O)N(R12e)—, —N(R12e)SO2N(R12e)—, —OC(O)—, or —C(O)N(R12e)—O—; andT2 is an optionally substituted C1-C6 alkylene chain wherein the alkylene chain optionally is interrupted by —N(R13)—, —O—, —S—, —S(O)—, —S(O)2—, —C(O)—, —C(O)O—, —C(O)N(R13)—, —S(O)2N(R13)—, —OC(O)N(R13)—, —N(R13)C(O)—, —N(R13)SO2—, —N(R13)C(O)O—, —N(R13)C(O)N(R13)—, —N(R13)S(O)2N(R13)—, —OC(O)—, or —C(O)N(R13)—O— or wherein T3 or a portion thereof optionally forms part of an optionally substituted 3-7 membered cycloaliphatic or heterocyclyl ring, wherein R13 is hydrogen or an optionally substituted C1-4aliphatic group;n is 0 to 4;W is selected from —C(R7)2—, —C(═C(R7)2)—, —C(R7)2O—, —C(R7)2NR7a—, —O—, —N(R7b)—, —S—, —S(O)—, —S(O)2—, —C(O)—, —C(O)NR7a—, or —N(R7a)C(O)—, wherein:
each occurrence of R7 is independently hydrogen, or an optionally substituted group selected from C1-6 aliphatic, 6-10-membered aryl, 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, —N(R7b)2, —OR7a, —SR7a, halo, or —CN;each occurrence of R7a is independently hydrogen or optionally substituted C1-6 aliphatic;each occurrence of R7b is independently hydrogen, optionally substituted C1-6 aliphatic, —C(O)R7a, or —S(O)2R7a; orwherein any two occurrences of R7, R7a, or R7b taken together with the atom to which they are bound, form an optionally substituted group selected from a 3-6-membered cycloaliphatic ring, 6-10-membered aryl, 3-6-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;or wherein any two occurrences of R7a and R2, or R7b and R2 taken together with the nitrogen atom to which they are bound, form an optionally substituted group selected from 3-6-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; G1 is N or —CR8, wherein R8 is H, —CN, halogen, -Z-R9, C1-6 aliphatic, or 3-10-membered cycloaliphatic, wherein:
Z is selected from an optionally substituted C1-3 alkylene chain, —O—, —N(R8a)—, —S—, —S(O)—, S(O)2—, —C(O)—, —CO2—, —C(O)NR8a—, —N(R8a)C(O)—, —N(R8a)CO2—, —S(O)2NR8a—, —N(R8a)S(O)2—, —OC(O)N(R8a)—, —N(R8a)C(O)NR8a—, —N(R8a)S(O)2N(R8a)—, or —OC(O)—;
R8a is hydrogen or an optionally substituted C1-4 aliphatic, andR9 is hydrogen or an optionally substituted group selected from C1-6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; and HY is wherein each occurrence of X5, X6 and X7 is —CR10;
wherein R10 is R10b, —V1—R10c, -T1-R10b, or —V1-T1-R10b wherein:
V1 is —NR11—, —NR11—C(O)—, —NR11—C(S)—, —NR11—C(NR11)—, —NR11C(O)OR10a—, —NR11C(O)NR11—, —NR11C(O)SR10a—, —NR11C(S)OR10a—,—NR11C(S)NR11—, —NR11C(S)SR10a—, —NR11C(NR11)OR10a—, —NR11C(NR11)NR11—, —NR11S(O)2—, —NR11S(O)2NR11—, —C(O)—, —CO2—, —C(O)NR11—, —C(O)NR11O—, —SO2—, or —SO2NR11—;each occurrence of R10a is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;T1 is an optionally substituted C1-C6alkylene chain wherein the alkylene chain optionally is interrupted by —N(R11)—, —O—, —S—, —S(O)—, —S(O)2—, —C(O)—, —C(O)O—, —C(O)N(R11)—, —S(O)2N(R11)—, —OC(O)N(R11)—, —N(R11)C(O)—, —N(R11)SO2—, —N(R11a)C(O)O—, —NR10a C(O)N(R10a)—, —N(R10a)S(O)2N(R10a)—, —OC(O)—, or —C(O)N(R11)—O— or wherein T1 forms part of an optionally substituted 3-7 membered cycloaliphatic or heterocyclyl ring;each occurrence of R10b is independently hydrogen, halogen, —CN, —NO2, —N(R11)2, —OR10a, —SR10a, —S(O)2R10a, —C(O)R10a, —C(O)OR10a, —C(O)N(R11)2, —S(O)2N(R11)2, —OC(O)N(R11)2, —N(R11)C(O)R10a, —N(R11)SO2R10a, —N(R11)C(O)OR10a, —N(R11)C(O)N(R11)2, or —N(R11)SO2N(R11)2, or an optionally substituted group selected from C1-6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;each occurrence of R10c is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, orR10a and R10c taken together with a nitrogen atom to which they are bound form an optionally substituted 4-7-membered heterocyclyl ring having 0-1 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur; each occurrence of R11 is independently hydrogen, —C(O)R11a, —CO2R11a, —C(O)N(R11a)2, —C(O)N(R11a)—OR11a, —SO2R11a, —SO2N(R11a)2, or an optionally substituted group selected from C1-6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
wherein each occurrence of R11a is independently hydrogen or an optionally substituted group selected from C1-6aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur. |
