| 发明名称 | Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding | ||
| 摘要 | Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.;The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases. | ||
| 申请公布号 | US9061068(B2) | 申请公布日期 | 2015.06.23 |
| 申请号 | US201012905212 | 申请日期 | 2010.10.15 |
| 申请人 | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY | 发明人 | Kim Kwang Meyung;Kwon Ick Chan;Choi Kuiwon;Huh Myung Sook;Lee Seung Young;Lee So Jin |
| 分类号 | C07H21/02;A61K47/48;C12N15/11;C12N15/87 | 主分类号 | C07H21/02 |
| 代理机构 | Ostrolenk Faber LLP | 代理人 | Ostrolenk Faber LLP |
| 主权项 | 1. A polymer-siRNA delivery carrier with the following structure in which a polymer (A) and a siRNA (B) are connected by using charge interaction and biodegradable covalent bonding at the same time: A-B wherein, “A” is chitosan or glycol chitosan as a polymer having positive charge and functional group, and “B” is a poly-siRNA in which a plurality of siRNAs are connected by biodegradable covalent bonding having a functional group at one end or both ends of the poly-siRNA. | ||
| 地址 | KR | ||