| 摘要 |
The invention comprises O-aryl O-methyl phosphoroamidothioates of the formula <FORM:0796484/IV (b)/1> wherein X is either chlorine or bromine and R is hydrogen, methyl, or ethyl. They may be obtained by reacting an O-aryl O-methyl phosphorochloridothioate of the formula <FORM:0796484/IV (b)/2> in the presence of an inert solvent with an excess of ammonia, methylamine, or ethylamine. The reaction is exothermic and takes place smoothly at a temperature in the range - 10 DEG to 30 DEG C. to form the desired product and ammonium hydrochloride or amine hydrochloride. Specified inert solvents are acetone, methyl ethyl ketone, carbon tetrachloride, and benzene. It is preferred to use at least two molecular proportions of ammonia or amine for each molecular proportion of the phosphorochloridothioate reagent. The reaction is preferably carried out in a water-miscible solvent using aqueous ammonia or aqueous amine but gaseous ammonia or alkyl amine may also be used. Examples are given for the production of compounds in which X is chlorine and R is hydrogen, methyl and ethyl respectively, and in which X is bromine and R is hydrogen and ethyl respectively. The products are stated to be effective as parasiticides (see Group VI) and may also be used as preservatives for paper, paint and wood. The O-aryl O-methyl phosphoro-chloridothioates used as starting materials may be obtained by reacting one molecular proportion of the corresponding O-aryl phosphorodichloridothioate with one molecular proportion of sodium methylate in an inert organic solvent such as benzene. Specified temperatures for this reaction are 30 DEG to 80 DEG C.ALSO:O-aryl O-methyl phosphoroamidothioates of the general formula: <FORM:0796484/VI/1> wherein X is either chlorine or bromine and R is hydrogen, methyl, or ethyl (see Group IV (b)) are stated to be effective as pesticides and for this purpose they may be dispersed on a finelydivided carrier and employed as dusts, or they may be used in oils or as constituents in water emulsions or in water dispersions. Specified products are those in which X is chlorine and R is hydrogen, methyl, and ethyl respectively, and in which X is bromine and R is hydrogen and ethyl respectively.
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