| 主权项 |
1. A piperidine derivative of the following formula 1, stereoisomers thereof or pharmaceutically acceptable salts thereof: wherein W is O or N—Rh; Ra, Rb and Rh are each independently H or C1-3 alkyl; Rc is —F or —C1-3 hyperfluoride alkyl; Rd and Re are each independently selected from the group consisting of H, halogen, —C1-5 alkyl and —C3-7 cycloalkyl, wherein —C1-5 alkyl and —C3-7 cycloalkyl are each independently unsubstituted or substituted with halogen, —CN, —OC1-5 alkyl or —C1-5 alkyl; or Rd and Re are combined to form a —C3-7 cycloalkyl, wherein the —C3-7 cycloalkyl is unsubstituted or substituted with halogen, —OC1-5 alkyl or —C1-5 alkyl;is selected from the group consisting of:wherein Rf1 and Rf2 are each independently H, halogen, —C1-5 alkyl, —C1-5 alkyl(OH), —OC1-5 alkyl or —CN;is selected from the group consisting of:wherein Rk1 and Rk2 are each independently H, halogen, —C1-5 alkyl, —C1-5 alkyl(OH), —OC1-5 alkyl or —CN;Q is H, —S(O)R1, —S(O)2R1, —C(O)R1, —C(O)OR1, —C(O)NHR1, —C(O)NR2R3, —S(O)2NHR1, —S(O)2NR2R3 or wherein R1 is H, —CF3, —C1-5 alkyl, 3 to 7-membered heterocyclic ring, C3-7 cycloalkyl, or Ar, R2 and R3 are each independently C1-5 alkyl, C3-7 cycloalkyl, 3 to 7-membered heterocyclic ring or Ar (in R1, R2 and R3, —C1-5 alkyl, 3 to 7-membered heterocyclic ring, C3-7 cycloalkyl and Ar may be each independently substituted with Rx1 and Rx2), or R2 and R3 together with the N atoms to which they are bonded may form a 5- or 6-membered heterocyclic aromatic or non-aromatic ring compound further having 0 to 3 members selected independently from the group consisting of N, O, S and C(O), wherein the heterocyclic aromatic or non-aromatic ring compound may be substituted with Rx1 and Rx2, wherein Ar is C6 monocyclic aromatic compound; or 5- or 6-membered heteroaryl group comprising 1 to 3 members selected from the group consisting of N, O and S, wherein Rx1 and Rx2 are each independently H, —OH, halogen, —CN, —CF3, 3- to 7-membered heterocyclic ring, —C1-5 alkyl, —C3-7 cycloalkyl, —C1-5 alkyl(OH), —C1-5 alkyl(OR4), —C1-5 alkyl(halogen), —C(O)NR4R5, —C(O)R4, —C(O)OR4, —S(O)2R4, —OR4,wherein R4 and R5 are each independently H, —C1-5 alkyl or —C3-7 cycloalkyl. |
