摘要 |
<p>Disclosed herein are polypeptides comprising or consisting of a synthetic amphipathic helical peptide or peptide analog, and nucleic acid molecules encoding such polypeptides. Also disclosed herein are methods of using the disclosed polypeptides, analogs, or nucleic acid molecules to treat and/or inhibit chronic kidney disease, as well as to treat and/or inhibit dyslipidemic or vascular disorders, such as methods to treat or prevent cardiovascular disease including atherosclerosis.</p> |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
YUEN, PETER;SOUZA, ANA;STAR, ROBERT;BOCHAROV, ALEXANDER;REMALEY, ALAN;EGGERMAN, THOMAS |