INDUCTION OF TUMOR HYPOXIA FOR CANCER THERAPY

摘要

PROBLEM TO BE SOLVED: To provide methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors.SOLUTION: A hypoxic region is created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g., tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.