SYSTEMS AND METHODS FOR PROCESSING FLUIDS

摘要

Systems and methods for processing fluid samples are disclosed. Fluid sample processing is accomplished using a series of microfluidic bump arrays include an automated and integrated system for sorting particles from a biological sample, lysing those particles to expose total RNA or DNA, purifying the RNA or DNA, processing the RNA or DNA by chemical or enzymatic modification, to select RNA or DNA molecules by size, or to generate, optionally, a sequencing library. The sequencing library is suitable for use in next generation sequencing (“NGS”).

主权项

1. A method for processing of a biological fluid, comprising:
separating at least one first cell from the biological fluid; applying at least one first treatment to the at least one separated cell to produce a first treated solution; applying at least one second treatment to the first treated solution to produce a second treated solution; and processing at least one of the first treated solution and the second treated solution using a deterministic lateral displacement to generate an output solution.