IAP ANTAGONISTS

摘要

There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.;

主权项

1. A compound of Formula (I)wherein:
X is —(CR16R17)m,or X is absent;
Y and Z are independently —O—, C═O, NR6 or are absent; R1 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkylaryl or optionally substituted aryl; R2 and R3 are independently optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted arylalkyl or optionally substituted aryl; R4 and R5 are independently optionally substituted alkyl or optionally substituted cycloalkyl; R6 is hydrogen or (C1-C3)alkyl; R7 and R8 are independently hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; R9 and R10 are independently hydrogen, optionally substituted alkyl, or R9 and R10 may be taken together to form a ring; R11 to R14 are independently hydrogen, halogen, optionally substituted alkyl or OR15; R15 is hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl; R16 and R17 are independently hydrogen, halogen or optionally substituted alkyl; R50 and R51 are independently optionally substituted alkyl, or R50 and R51 are taken together to form a ring; m and n are independently an integer from 0-4; o and p are independently an integer from 0-3; q is an integer from 0-4; and r is an integer from 0-1; or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.