发明名称 |
TREATMENT OF COGNITIVE IMPAIRMENT OF HUNTER SYNDROME BY INTRATHECAL DELIVERY OF IDURONATE-2-SULFATASE |
摘要 |
The present invention, provides a method of treating cognitive impairment of Hunter syndrome. Among other things, the present invention provides a method comprising a step of administering intrathecally to a subject in need of treatment a recombinant iduronate-2-sulfatase (I2S) enzyme at a therapeutically effective dose and an administration interval for a treatment period sufficient to improve, stabilize or reduce declining of one or more cognitive, adaptive, motor, and/or executive functions relative to a control |
申请公布号 |
WO2013096912(A3) |
申请公布日期 |
2015.06.18 |
申请号 |
WO2012US71495 |
申请日期 |
2012.12.21 |
申请人 |
SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
BARBIER, ANN;MCCAULEY, THOMAS;RICHARD, CHARLES, W., III |
分类号 |
A61K38/46 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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