发明名称 |
METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA |
摘要 |
The present invention provides compounds of any one of Formulae (I) to (V) (e.g., compounds of any one of Formulae (I-l) to (1-9)), and methods for treating Waldenstrom' s macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin- 1 receptor- associated kinase 1 (IRAKI), interleukin- 1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase- 1 (TAK1), and/or a Src family kinase. |
申请公布号 |
WO2015089481(A2) |
申请公布日期 |
2015.06.18 |
申请号 |
WO2014US70167 |
申请日期 |
2014.12.12 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
TREON, STEVEN, P.;BUHRLAGE, SARA, JEAN;GRAY, NATHANAEL;TAN, LI;YANG, GUANG |
分类号 |
A61K31/4436;C07D409/04 |
主分类号 |
A61K31/4436 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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