RICE BRAN-LIPIDS BASED FORMULATION AND PROCESS FOR PREPARATION THEREOF FOR SELECTIVE DELIVERY OF GENES TO CANCER CELLS

摘要

The present invention relates to a formulation in which glycolipids and phospholipids, isolated from rice bran gum samples, were used in conjunction with gene carrying lipids to test its efficacy in delivering genes to cancer cells selectively. This formulation did not mediate efficient delivery of genes to non-cancerous cells, thus, showing potential use of this formulation to deliver anticancer therapeutics to cancer cells without eliciting treatment related toxicity to normal cells

主权项

1. A liposomal formulation useful for selective targeting and delivery of genes or genetic products to cancer cells, comprising:
(a) a cationic lipid in the range of 7-40 mole % of all constituent lipids; (b) a co-lipid in the range of 7-40 mole % of all constituent lipids, said co-lipid is characterized in facilitating successful intracellular delivery of the biologically active molecules such as genes and gene products; (c) rice bran glycolipids and/or phospholipids as adjuvant lipids in the range of 20-85 mole % of all constituent lipids, wherein said glycolipids and/or phospholipids are characterized in enhancing the transfection efficiency of the formulation; and (d) a gene or genetic product of interest.