| 摘要 |
PROBLEM TO BE SOLVED: To provide selective inhibitors of caspases, and methods of their uses for the prevention and/or treatment of caspase-mediated diseases such as sepsis, myocardial infarction, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative disease (e.g., multiple sclerosis (MS) and Alzheimer's, Parkinson's, and Huntington's diseases).SOLUTION: The present invention relates to compounds represented by formula IIA etc. or prodrugs thereof, or pharmaceutically acceptable salts thereof, or compounds labeled with detectable labels or affinity tags. |
