发明名称 |
COMPOSITIONS AND METHODS COMPRISING BINDING PROTEINS FOR ADALIMUMAB |
摘要 |
Compositions and methods comprising proteins that bind specifically to adalimumab are disclosed herein. Adalimumab is a monoclonal antibody specific for the cytokine TNF-α and was developed to treat TNF-α mediated inflammatory diseases. In one aspect of the instant invention, the binding proteins are antibodies directed toward adalimumab. These antibodies, including binding fragments thereof, can be used in a clinical setting as well as for research and development. For example, these anti-adalimumab antibodies can be employed to neutralize adalimumab. |
申请公布号 |
US2015166678(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
US201514630322 |
申请日期 |
2015.02.24 |
申请人 |
AbbVie Biotechnology Ltd |
发明人 |
Kaymakcalan Zehra;Xiong Limin |
分类号 |
C07K16/42;A61K45/06;G01N33/94;A61K39/395 |
主分类号 |
C07K16/42 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated monoclonal antibody, or an antigen binding portion thereof, which binds adalimumab. |
地址 |
Hamilton BM |