PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING STRESS URINARY INCONTINENCE OR MIXED INCONTINENCE, AND METHOD FOR SCREENING COMPOUNDS TO BE INCLUDED IN SAID PHARMACEUTICAL COMPOSITION

摘要

[Problem] To provide a pharmaceutical composition for treating or preventing urinary incontinence on the basis of a novel mechanism of action, and a method for screening a compound to be comprised in the pharmaceutical composition as an active ingredient. [Means for Solution] The present invention relates to a pharmaceutical composition for treating or preventing stress urinary incontinence or mixed urinary incontinence, comprising a compound having a melatonin receptor activation action as an active ingredient. Examples of the active ingredient include melatonin, ramelteon, agomelatine, tasimelteon, TIK-301, and the like. Further, the present invention relates to a method for screening a compound to be comprised in a pharmaceutical composition for treating or preventing stress urinary incontinence or mixed urinary incontinence as an active ingredient, consisting of a step of measuring a melatonin receptor activation, a step of measuring the contraction of the isolated urethra, a step of measuring the urethral pressure, and the like.