Alprostadil and lidocaine treatment of premature ejaculation

摘要

Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a vasoactive prostaglandin, a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.

主权项

1. A method of treating premature ejaculation in a patient complaining of premature ejaculation comprising:
administering meatally to a patient in need of treatment of premature ejaculation an ejaculation latency prolonging amount of a semi-solid composition comprising: 2.5 percent-5.0 percent by weight based on the weight of the composition of lidocaine as a topical anesthetic; about 0.1 mg to about 0.5 mg of a vasoactive prostaglandin selected from the group consisting of prostaglandin E1, a pharmaceutically acceptable salt thereof a lower alkyl ester thereof wherein the lower alkyl is a straight chain or branched chain alkyl containing one to four carbon atoms, and a mixture thereof; a polymeric thickener selected from the group consisting of a shear-thinning polysaccharide gum and a shear-thinning polyacrylic acid polymer; a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof; and a buffer system that provides a buffered pH value for said composition in the range of about 3 to about 7.4; wherein administering the semi-solid composition confers prolongation of baseline ejaculation latency time to the patient, thereby treating premature ejaculation in the patient.