Methods of healing or preventing inflammation, damage and other changes that occur prior to, during or immediately after a myocardial event with thymosin beta 4, analogues, isoforms and other derivatives

摘要

Inflammation or damage associated with myocardial events is treated or prevented by administration of an angiogenesis-inducing, anti-inflammatory peptide such as Thymosin β4, an isoform of Thymosin β4 or oxidized Thymosin β4.

主权项

1. A method of enhancing myocardial tissue cell differentiation in a subject in need thereof, wherein cardiac endothelial cells are transformed to mesenchymal cells, comprising administering to said subject a composition comprising an effective amount of thymosin beta 4 (Tβ4) and a pharmaceutically acceptable carrier, wherein said Tβ4 is administered in a dosage of about 0.1 to 50 micrograms and at a concentration of 0.001-10% by weight.