LIVESTOCK WITH GENETICALLY MODIFIED PROLACTIN RECEPTOR

摘要

Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.

主权项

1. A genetically modified livestock animal from a first breed comprising an exogenous allele of a gene from another species or a second breed, said exogenous allele replacing a native allele of the gene, wherein a genome of the first breed is free of meiotic recombination with a genome of the other species or the second breed and the exogenous allele is selected from the group consisting of prolactin receptor (PRLR), and pleiomorphic adenoma gene 1 (Plag1).