SKIN PERMEATING AND CELL ENTERING (SPACE) PEPTIDES AND METHODS OF USE THEREFOR

摘要

Compositions that facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells are provided. The compositions may include a peptide, an active agent, or a carrier that includes the active agent. The peptide is associated with and/or conjugated to the active agent, the carrier, or both. The carrier is a micelle, a liposome, an ethosome, and combinations thereof. The composition is capable of penetrating a stratum corneum (SC) layer or a cell when contacted therewith. The composition may further include one or more free peptides. Also provided are methods for delivering active agents to subjects, methods for treating subjects having dermatological diseases, and methods for attenuating expression of mRNAs of subjects in need thereof and/or for treating diseases and/or disorders thereby.