发明名称 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
摘要 <p>The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention are represented by formula (I-A) and formula (I-B); or a pharmaceutically acceptable salt, wherein the variables are as defined herein.</p>
申请公布号 WO2015084384(A1) 申请公布日期 2015.06.11
申请号 WO2013US73482 申请日期 2013.12.06
申请人 VERTEX PHARMACEUTICALS INCORPORATED 发明人 BOYALL, DEAN;CHARRIER, JEAN-DAMIEN;DAVIS, CHRIS;DURRANT, STEVEN;ETXEBARRIA I JARDI, GORKA;FRAYSSE, DAMIEN;KAY, DAVID;KNEGTEL, RONALD;PINDER, JOANNE
分类号 C07D471/04;A61K31/437;A61P35/00;C07D487/04 主分类号 C07D471/04
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