发明名称 |
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS |
摘要 |
Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described. |
申请公布号 |
US2015158826(A1) |
申请公布日期 |
2015.06.11 |
申请号 |
US201214344709 |
申请日期 |
2012.09.14 |
申请人 |
NEUPHARMA, INC. |
发明人 |
Qian Xiangping;Zhu Yong-Liang |
分类号 |
C07D241/42;A61K45/06;C07D401/04;C07D403/04;A61K31/498;A61K31/5377 |
主分类号 |
C07D241/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Fremont CA US |