ANTIMICROBIAL COMPOSITIONS CONTAINING FREE FATTY ACIDS

摘要

The invention concerns antimicrobial compositions comprising free fatty acids emulsified with membrane lipids or hydrolysed derivatives thereof, and pharmaceutical formulations comprising same. The compositions can be used in the treatment of prophylaxis of microbial infections. They can also regulate the rate of blood clotting rendering them suitable for incorporation in catheter locking solutions and for use in wound care.

主权项

1. A method of treating or preventing a microbial infection and regulating the rate of blood-clotting in a subject in need thereof, the method comprising administering to the subject an effective amount of an antimicrobial and blood-clotting regulatory composition for use in blood contact applications selected from the group consisting of surgical irrigation, wound care, catheter locking solutions, and the coating of catheters and other medical devices for insertion through the skin or into a bodily orifice or cavity, the composition comprising:
(a) one or more free fatty acids selected from the group consisting of caproic, caprylic, capric, lauric, palmitic, stearic, oleic, linoleic and linolenic acids and mixtures thereof; and (b) one or more membrane lipids or a hydrolysed derivative thereof, as emulsifying agent for the free fatty acid(s).