MARKER PEPTIDE FOR DETERMINING RISK OF DEVELOPING METABOLIC SYNDROME, AND USE THEREOF

摘要

It is an object of the present invention to provide a marker substance capable of accurately determining a risk of developing metabolic syndrome in vivo. That is, the present invention provides the followings: a marker peptide for determining the risk of developing the metabolic syndrome; an antibody or an aptamer bound to the marker peptide for determining the risk of developing the metabolic syndrome; a microarray in which the antibody or the aptamer bound to the marker peptide for determining the risk of developing the metabolic syndrome has been immobilized on a carrier; a method for determining the risk of developing the metabolic syndrome, comprising measuring an amount or the presence or absence of the marker peptide for determining the risk of developing the metabolic syndrome in a biological sample collected from a subject; and a kit for determining the risk of developing the metabolic syndrome, comprising the antibody or the aptamer or comprising the microarray.

主权项

1. A marker peptide that is selected from the group consisting of:
(A) a polypeptide comprising ten or more consecutive amino acid residues in the amino acid sequence of SEQ ID NO:1; (B) a polypeptide comprising an amino acid sequence having one or more amino acid deletions, additions, substitutions or insertions in ten or more consecutive amino acid residues in the amino acid sequence of SEQ ID NO:1; (C) a polypeptide comprising an amino acid sequence having 90% or more homology to ten or more consecutive amino acid residues in the amino acid sequence of SEQ ID NO:1; (D) a polypeptide comprising ten or more consecutive amino acid residues in an amino acid sequence having one or several amino acid deletions, additions, substitutions or insertions in the amino acid sequence of SEQ ID NO:1; (E) a polypeptide comprising ten or more consecutive amino acid residues in an amino acid sequence having 90% or more homology to the amino acid sequence of SEQ ID NO:1; (F) a polypeptide comprising ten or more consecutive amino acid residues in the amino acid sequence of SEQ ID NO:2; (G) a polypeptide comprising an amino acid sequence having one or more amino acid deletions, additions, substitutions or insertions in ten or more consecutive amino acid residues in the amino acid sequence of SEQ ID NO:2; (H) a polypeptide comprising an amino acid sequence having 90% or more homology to ten or more consecutive amino acid residues in the amino acid sequence of SEQ ID NO:2; (I) a polypeptide comprising ten or more consecutive amino acid residues in an amino acid sequence having one or several amino acid deletions, additions, substitutions or insertions in the amino acid sequence of SEQ ID NO:2;and (J) a polypeptide comprising ten or more consecutive amino acid residues in an amino acid sequence having 90% or more homology to the amino acid sequence of SEQ ID NO:2; wherein said marker peptide is capable of being used as a marker for determining the risk of developing metabolic syndrome.