NEW NK3 RECEPTOR AGONIST

摘要

Provided is a new NK3 receptor selective ligand which is expected to have high activity and high selectivity, and to act in a sustained manner in vivo.　A compound expressed by formula (I) X1 - A2 - A3 - X4 - X5 - Met - NH2 [the symbols in the formula are as set forth in the description] or a pharmaceutically acceptable salt thereof has a highly active and highly selective NK3 receptor agonist activity, and is effective as a drug for the treatment of disorders associated with an excess or deficiency in the secretion of tachykinins, for example as a pharmaceutical for the treatment of pain or for the improvement of sexual dysfunction accompanying excess or deficiency in the secretion of sex hormones.