RECOMBINANT BACTERIOPHAGE FOR DETECTION OF NOSOCOMIAL INFECTION

摘要

PROBLEM TO BE SOLVED: To provide a method for detecting bacterial nosocomial infection.SOLUTION: Disclosed methods may be utilized for continuous in vivo monitoring of a potential bacterial infection site or may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of infection. Disclosed methods include utilization of bacteriophage to deliver to pathogenic bacteria a translatable genetic sequence encoding an optically detectable marker or an enzyme capable of producing an optically detectable marker. Upon detection of the optical signal produced by the marker, medical personnel may be alerted to the presence of pathogenic bacteria at the site of inquiry. Any bacterial causative agent of HAI may be detected according to disclosed methods.