TRI-SUBSTITUTED GLYCEROL COMPOUNDS FOR USE IN THE TREATMENT OF CLINICALLY ISOLATED SYNDROME AND/OR MULTIPLE SCLEROSIS

摘要

The present invention relates to tri-substituted glycerol compounds according to formula (I) as described herein for use in the treatment of clinically isolated syndrome, relapsing remitting multiple sclerosis (RR-MS) and/or secondary progressive multiple sclerosis (SP-MS). The tri-substituted glycerol compounds according to formula (I) as described herein may also be used for the treatment of multiple sclerosis patients not adequately responding to interferon therapy. The present invention also relates to a tri-substituted glycerol compound as described herein, for use as a medicament, wherein the tri-substituted glycerol compound is administered in combination with at least one further pharmaceutically active compound.

主权项

1. A method of treating clinically isolated syndrome, relapsing remitting multiple sclerosis (RR-MS), and/or secondary progressive multiple sclerosis (SP-MS) in a patient comprising administering an effective amount of a tri-substituted glycerol compound of formula (I)or an enantiomer or diastereomer or a pharmaceutically acceptable salt thereof, wherein
X is selected from the group consisting of phosphate and sulfate; R1 is selected from the group consisting of C16-C20 alkyl; R2 is selected from the group consisting of C1-C3 alkyl and C1-C3 hydroxyalkyl; R3 is selected from the group consisting of hydrogen and C1-C3 alkyl; R4 is selected from the group consisting of C1-C3 alkyl and C3-C6 cycloalkyl; and R5 is independently selected from the group consisting of hydrogen and methyl, to the patient, thereby treating clinically isolated syndrome, relapsing remitting multiple sclerosis (RR-MS), and/or secondary progressive multiple sclerosis (SP-MS) in the patient.