发明名称 |
MODULATION OF TISSUE TRANSGLUTAMINASE ACTIVATION IN DISEASE |
摘要 |
<p>Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activation of TG2 associated with enteric inflammatory disorders, which disorders may include celiac disease, irritable bowel syndrome, Crohn's Disease, dermatitis herpetiformis, and the like. In other embodiments of the invention, methods are provided for reducing undesirable paracellular transport in enteric tissues, in particular the paracellular transport of molecules greater than about 500 mw, e.g. peptides, including without limitation immunogenic gluten peptides.</p> |
申请公布号 |
EP2721169(A4) |
申请公布日期 |
2015.06.10 |
申请号 |
EP20120801941 |
申请日期 |
2012.06.19 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
DIRAIMONDO, THOMAS;JIN, XI;KLOECK, CORNELIUS;KHOSLA, CHAITAN |
分类号 |
A61P1/00;A61K31/4164;A61K31/4184;A61K31/4188;A61K31/423;A61K31/426;A61K31/428;A61K31/4709;A61K31/473;A61K31/5377 |
主分类号 |
A61P1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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