ASSEMBLY FOR NUCLEIC ACID SEQUENCING BY MEANS OF TUNNEL CURRENT ANALYSIS

摘要

An assembly for nucleic acid sequencing by tunnel current analysis has at least two electrically conductive particles having a diameter from 1 nm to 100 nm and at least two electrically insulating particles having a diameter from 1 nm to 100 nm. The particles are in particular spherically shaped. The assembly also has at least two first electrodes for contacting the electrically conductive particles and a substrate on which the first electrodes and the particles are arranged. The four particles are arranged substantially in a planar square. The conductive particles lie diagonally opposite each other, and the insulating particles lie diagonally opposite each other. The gap between the four particles is used as a solid-state nanopore for nucleic acid sequencing.