The technology provided herein relates to novel human antibodies against Plasmodium parasites, in particular against the malaria parasite Plasmodium falciparum. The present disclosure pertains to antibodies against merozoite surface protein 10 (MSP10). These antibodies have high affinity e.g. to Plasmodium falciparum schizonts and merozoites, inhibit the reinvasion of merozoites into erythrocytes and thereby neutralize parasitic multiplication.
申请公布号
EP2879706(A1)
申请公布日期
2015.06.10
申请号
EP20130748000
申请日期
2013.07.31
申请人
FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
发明人
FENDEL, ROLF;KLOCKENBRING, TORSTEN;BARTH, STEFAN;KAPELSKI, STEPHANIE;MASKUS, DOMINIKA;FISCHER, RAINER;REIMANN, ANDREAS