| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a new prophylactic or treating agent of inflammatory bowel diseases including a decoy oligonucleotide as an effective component, and efficacious even by intravenous administration. <P>SOLUTION: A hairpin type double-stranded oligonucleotide having a structure, in which an oligonucleotide having a specific base sequence and its complementary strand are linked together through a specific linker, exerts NF-κB binding affinity higher than that of heretofore known NF-κB decoy. The oligonucleotide having the specific structure, among such oligonucleotides, can prominently suppress inflammation in bowel tissue even by intravenous administration in a naked form, without necessitating special delivery technique such as virus envelope vector. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
