发明名称 |
INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6 |
摘要 |
<p>Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula /: Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*1 is—H or—CH3; and Y is Formula (II) or Formula (III), wherein R2 is—H,—CH3 or C1-4 alkyloxycarbonyl; and RS7.1, RS7.2 and RS8.1 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.</p> |
申请公布号 |
EP2879681(A1) |
申请公布日期 |
2015.06.10 |
申请号 |
EP20130825181 |
申请日期 |
2013.08.02 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
AMIDON, BENJAMIN, S.;CARDIN, DAVID, P.;GOULD, ALEXANDRA, E.;GREENSPAN, PAUL, D.;HARRISON, SEAN, J. |
分类号 |
C07D487/04;A61K31/519;A61K31/70;A61P25/28;A61P29/00;A61P35/00;A61P37/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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