| 发明名称 | Inhibitors of influenza viruses replication | ||
| 摘要 | Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. | ||
| 申请公布号 | US9051319(B2) | 申请公布日期 | 2015.06.09 |
| 申请号 | US201314099054 | 申请日期 | 2013.12.06 |
| 申请人 | Vertex Pharmaceuticals Incorporated | 发明人 | Charifson Paul S.;Clark Michael P.;Bandarage Upul K.;Bethiel Randy S.;Boyd Michael J.;Davies Ioana;Deng Hongbo;Duffy John P.;Farmer Luc J.;Gao Huai;Gu Wenxin;Kennedy Joseph M.;Ledford Brian;Ledeboer Mark W.;Maltais Francois;Perola Emanuele;Wang Tiansheng |
| 分类号 | A61K31/454;C07D471/04 | 主分类号 | A61K31/454 |
| 代理机构 | Honigman Miller Schwartz and Cohn LLP | 代理人 | Honigman Miller Schwartz and Cohn LLP ;Weber Andrew N.;O'Brien Jonathan P. |
| 主权项 | 1. A compound of the formulaor a pharmaceutically acceptable salt thereof. | ||
| 地址 | Boston MA US | ||