Imidazolyl methyl piperidine T-type calcium channel antagonists

摘要

The present invention is directed to imidazolyl methyl piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

主权项

1. A compound of the formula I: wherein: R1a, R1b and R1c are independently selected from the group consisting of:
(1) hydrogen,(2) halogen,(3) hydroxyl,(4) C1-6alkyl, which is unsubstituted or substituted with halogen, hydroxyl, phenyl, —O—C1-6alkyl, —O—(CO)C1-6alkyl, or C3-6cycloalkyl, and(5) —O—C1-6alkyl, which is unsubstituted or substituted with halogen, hydroxyl, phenyl, —O—C1-6alkyl, —O—(CO)C1-6alkyl, or C3-6cycloalkyl,or two of adjacent R1a, R1b and R1c are joined together to form an oxadiazole ring; R2a and R2b are independently selected from the group consisting of:
(1) hydrogen,(2) halogen,(3) hydroxyl,(4) C1-6alkyl, which is unsubstituted or substituted with halogen, hydroxyl, phenyl, —O—C1-6alkyl, —O—(CO)C1-6alkyl, or C3-6cycloalkyl, and(5) phenyl, which is unsubstituted or substituted with halogen, hydroxyl, phenyl, —O—C1-6alkyl, —O—(CO)C1-6alkyl, or C3-6cycloallcyl;provided that formula I is not the following compound:(4-fluorophenyl)(1-((2-phenyl-1H-imidazol-4-yl)methyl)piperidin-4-yl)methanone; or a pharmaceutically acceptable salt thereof.