Cold organ preservation composition and method of use

摘要

The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods.

主权项

1. A method for the cold preservation of an organ which comprises contacting said organ with a cold organ preservation composition that comprises:
cardiotrophin-1 and a cold organ preservation solution at a temperature of between 0° C. and 25° C., thereby cold preserving the organ, wherein the organ is a kidney and wherein the kidney is isolated by extraction from a live or dead donor, or is in a live or dead donor.