A NOVEL PROCESS FOR THE PREPARATION OF AMORPHOUS FORM OF TOLVAPTAN

摘要

The present invention provides a novel process for the preparation of amorphous form of tolvaptan active pharmaceutical ingredient. The process comprises, providing a solution of tolvaptan active pharmaceutical ingredient in an organic solvent, removing solvent from the solution of tolvaptan active pharmaceutical ingredient by agitated thin film drying and isolating amorphous form of tolvaptan active pharmaceutical ingredient.