CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS

摘要

The present invention discloses a compound comprising a carboxylic acid derivative of the structure wherein Y, at each occurrence, is independently selected from the group consisting of C(O), N, CR1, C(R2)(R3), NR5, CH, O and S; q is an integer of from 3 to 10; A is selected from the group consisting of O, S, C(R16)(R) and NR6; 10 E is selected from the group consisting of CH2, O, S, and NR7; J is selected from the group consisting of O, S and NR6; T is selected from the group consisting of C(O) and (CH2)b wherein b is an integer of from 0 to 3; M is selected from the group consisting of C(R9)(R10) and (CH12)u, wherein u is an integer of from 0 to 3; L is selected from the group consisting of O, NR11, S, and (CH2), wherein n is an integer of 0 or 1; X is selected from the group consisting of CO2B, PO3H2, SO3H, SO2NH2, SO2NHCOR12, OPO3H2, C(O)NHC(O)R13, C(O)NHSO2R14, hydroxyl, tetrazolyl and hydrogen; W is selected from the group consisting of C, CR15and N; and B, B, R1 R2, R3, R4, R5, R6, R7, R8, R9, R10 R11, R, 12R,13 R,14 R,15, R16 and R17 are as defined in the specification with the proviso that when A is C(R16)(R17), E is not NR7 and pharmaceutical compounds comprising the compound.