Positive Allosteric Modulators of MGLUR2

摘要

The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system. Formula (I):;

主权项

1. A compound of formula I wherein: A is Ar1—Y—Z; B is hydrogen or alkyl; or A and B together with the nitrogen to which they are attached form ring A; R1 is selected from the group consisting of hydrogen, cyano, halo, alkyl, haloalkyl, (cycloalkyl)alkyl, cycloalkyl, alkoxy, and haloalkoxy; R2 is selected from the group consisting of alkyl, haloalkyl, (cycloalkyl)alkyl, benzyl, and cycloalkyl; R3 is hydrogen, alkyl, haloalkyl, or cycloalkyl; Ar1 is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, or triazinyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, cycloalkyl, alkoxy, and haloalkoxy; Ar2 is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, or triazinyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, hydroxy, alkoxy, (cycloalkyl)alkoxy, haloalkoxy, and alkoxycarbonyl; X1 is CH or N; X2 is CR3 or N; X3 is CH or N; provided that one of X2 and X3 is N, thus when X2 is N, X3 is CH and when X3 is N, X2 is CR3; Y is C3-6 cycloalkyl substituted with 0-2 halo or alkyl substituents; and Z is a bond or C1-3 alkyl; ring A is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 1 Ar2 or (Ar2)alkyl substituent and is also substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, and haloalkoxy; or ring A is selected from the group consisting of or a pharmaceutically acceptable salt thereof.