LIPOPROTEIN COMPLEXES AND MANUFACTURING AND USES THEREOF

摘要

The present disclosure relates to lipoprotein complexes and lipoprotein populations and their use in the treatment and/or prevention of dyslipidemic diseases, disorders, and/or conditions. The disclosure further relates to recombinant expression of apolipoproteins, purification of apolipoproteins, and production of lipoprotein complexes using thermal cycling-based methods.

主权项

1. A population of lipoprotein complexes, each comprising a lipid fraction and an apolipoprotein fraction consisting essentially of an Apolipoprotein A-I (“ApoA-I”), wherein the lipoprotein complexes are at least 85% homogeneous, as reflected by a single peak in gel permeation chromatography.