SYSTEMS AND METHODS FOR DELIVERY OF A THERAPEUTIC AGENT

摘要

Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

主权项

1. A nerve modification device for altering nerve function in a bronchial airway of a patient, the nerve modification device comprising:
a main catheter body configured to extend though a trachea into the bronchial airway; at least one energy applicator having at least one energy emitter configured to emit energy laterally relative to the main catheter body; and a movable mechanism to move the at least one energy applicator laterally within the bronchial airway such that the at least one energy emitter contacts a first portion of a circumference of the airway wall, wherein the nerve modification device is adapted to deliver energy from the at least one energy emitter to produce an energy field concentrated in a target region in the wall of the bronchial airway in a first lateral direction from the catheter body to alter nerve cells within the target region.