发明名称 |
BISPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING HER2 |
摘要 |
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer. |
申请公布号 |
WO2015077891(A1) |
申请公布日期 |
2015.06.04 |
申请号 |
WO2014CA51140 |
申请日期 |
2014.11.27 |
申请人 |
ZYMEWORKS INC. |
发明人 |
WEISSER, NINA E.;NG, GORDON YIU KON;WICKMAN, GRANT RAYMOND;DIXIT, SURJIT BHIMARAO;ESCOBAR-CABRERA, ERIC;SANCHES, MARIO |
分类号 |
C07K16/46;A61K39/395;A61K47/48;A61P35/00;C07K16/28;C12N5/10;C12N15/13;C40B40/08 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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