发明名称 |
ANTIBODIES FOR EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3) DIRECTED TO DOMAIN III AND DOMAIN IV OF HER3. |
摘要 |
<p>The present invention relates to antibodies or fragments thereof that bind to a non-linear epitope within domain 3 of the HER3 receptor and inhibit both ligand-dependent and ligand-independent signal transduction. The invention also relates antibodies or fragments thereof that bind to amino acid residues within domains 3-4 of HER3 and inhibit both ligand-dependent and ligand-independent signal transduction; and compositions and methods of use of such antibodies or fragments thereof.</p> |
申请公布号 |
MX2014006731(A) |
申请公布日期 |
2015.06.04 |
申请号 |
MX20140006731 |
申请日期 |
2012.12.04 |
申请人 |
NOVARTIS AG |
发明人 |
WINFRIED ELIS;SETH ETTENBERG;ANDREW PAUL GARNER;NICOLE HAUBST;HEATHER HUET;CHRISTIAN CARSTEN SILVESTER KUNZ;ELIZABETH ANNE REISINGER SPRAGUE;QING SHENG |
分类号 |
C07K16/32 |
主分类号 |
C07K16/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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