TRAMADOL HYDROCHLORIDE AND PARACETAMOL ORALLY DISINTEGRATING COMPOSITION AND PROCESS FOR PREPARING THE SAME

摘要

Disclosed is a tramadol hydrochloride and paracetamol composition, comprising: about 2.5 to about 5 percent by weight of tramadol hydrochloride; about 25 to about 30 percent by weight of paracetamol; about 1.25 to about 1.75 percent by weight of colloidal silicon dioxide;about 0.25 to about 0.35 percent by weight of povidone K-30; about 4.5 to about 5.5 percent by weight of ethyl cellulose N7; about 1.5 to about 2 percent by weight of mannitol 25; about 20 to about 25 percent by weight of mannitol 400; about 20 to about 25 percent by weight of mannitol 35; about 9 to about 11 percent by weight of a disintegrant; about 3 to about 5 percent by weight of a sweetener; about 1 to about 1.5 percent by weight of a flavorant; and about 0.5 to about 1.5 percent by weight of a lubricant.