发明名称 |
QUINAZOLINE COMPOUNDS |
摘要 |
<p>The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.</p> |
申请公布号 |
WO2015079251(A1) |
申请公布日期 |
2015.06.04 |
申请号 |
WO2014GB53537 |
申请日期 |
2014.11.28 |
申请人 |
CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
GOLDBERG, KRISTIN;HAMILTON, NIALL;JONES, STUART;JORDAN, ALLAN;LYONS, AMANDA;NEWTON, REBECCA;OGILVIE, DONALD;WASZKOWYCZ, BOHDAN |
分类号 |
C07D403/12;A61K31/517;A61P35/00;C07D239/94;C07D401/12;C07D405/12;C07D413/12 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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